منابع مشابه
Aging of Cloned Animals: A Mini-Review.
The number of species for which somatic cell nuclear transfer (SCNT) protocols are established is still increasing. Due to the high number of cloned farm, companion, and sport animals, the topic of animal cloning never ceases to be of public interest. Numerous studies cover the health status of SCNT-derived animals, but very few cover the effects of SCNT on aging. However, only cloned animals t...
متن کاملFrontiers of Model Animals for Neuroscience:Two Prosperous Aging Model Animals forPromoting Neuroscience Research
A model animal showing spontaneous onset is a useful tool for investigating the mechanism of disease. Here, I would like to introduce two aging model animals expected to be useful for neuroscience research: the senescence-accelerated mouse (SAM) and the klotho mouse. The SAM was developed as a mouse showing a senescence-related phenotype such as a short lifespan or rapid advancement of senescen...
متن کاملWhy Animals Die: An Introduction to the Pathology of Aging.
Commentaries Cause-of-Death Analysis in Rodent Aging Studies J. M. Snyder, J. M. Ward, and P. M. Treuting . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 233 The Vital Role of Pathology in Improving Reproducibility and Translational Relevance of Aging Studies in Rodents P. M. Treuting, ...
متن کاملThe natural history of telomeres: tools for aging animals and exploring the aging process.
We have been exploring the use of telomere length as a technique to age animals. If telomere restriction fragments (TRFs) shorten predictably with age in a particular tissue, then measurement of TRFs will allow estimation of ages of animals when age cannot be measured directly. This would be particularly useful in population studies where tissue samples can be collected, but age of individuals ...
متن کامل[Analysis of aging-related oxidative stress status in normal aging animals and development of anti-aging interventions].
Since Harman proposed the "free-radical theory of aging", oxidative stress is postulated to be a major causal factor of senescence. Accumulation of oxidative stress-induced oxidatively modified macromolecules including protein, DNA, and lipid, were found in tissues during the aging process. However, it is not necessarily clear which factor is more critical for an increase in endogenous reactive...
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ژورنال
عنوان ژورنال: Rigakuryoho Kagaku
سال: 2004
ISSN: 1341-1667,2434-2807
DOI: 10.1589/rika.19.169